1190043-13-0
1190043-13-0
Chemical Structure
Alosetron-d3
Synonym(s): GR 68755-d3;GR 68755X-d3
- CAS No.: 1190043-13-0
- Formula:C17H15D3N4O
- Molecular Weight:297.37
IUPAC Name: 5-(methyl-d3)-2-((4-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
InChIKey: JSWZEAMFRNKZNL-BMSJAHLVSA-N
SMILES: O=C1N(CC2=C(C)N=CN2)CCC(N3C([2H])([2H])[2H])=C1C4=C3C=CC=C4
Biological Activity: Alosetron-d3 is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].
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Alosetron-d3 | Alosetron-d3 is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist. | |||||||||||||||||||||
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Alosetron | 96.26% | Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects. | ||||||||||||||||||||
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References
Keywords
