121346-33-6
121346-33-6
Chemical Structure
SR33805 oxalate
- CAS No.: 121346-33-6
- Formula:C34H42N2O9S
- Molecular Weight:654.77
IUPAC Name: N-(3,4-dimethoxyphenethyl)-3-(4-((3-isopropyl-1-methyl-1H-indol-2-yl)sulfonyl)phenoxy)-N-methylpropan-1-amine oxalate
InChIKey: MZWPPDAHWIKZID-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C(N3C)=C(C(C)C)C4=C3C=CC=C4)=O.O=C(O)C(O)=O
Biological Activity: SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts[1][2].
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SR33805 oxalate | SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts. | |||||||||||||||||||||
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References
- [1]. Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5. [Content Brief]
- [2]. Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9. [Content Brief]
