1217617-73-6
Chemical Structure
Volinanserin-d4 hydrochloride
Synonym(s): MDL100907-d4 hydrochloride; M 100907-d4 hydrochloride
- CAS No.: 1217617-73-6
- Formula:C22H25D4ClFNO3
- Molecular Weight:413.95
IUPAC Name: (R)-(2,3-dimethoxyphenyl)(1-(2-(4-fluorophenyl)ethyl-1,1,2,2-d4)piperidin-4-yl)methanol hydrochloride
InChIKey: SGTCZHOIXUDOLR-XBZIDIQDSA-N
SMILES: [C@H](O)(C1=C(OC)C(OC)=CC=C1)C2CCN(C(C(C3=CC=C(F)C=C3)([2H])[2H])([2H])[2H])CC2.Cl
Biological Activity: Volinanserin-d4 (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity[1][2].
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Volinanserin-d4 hydrochloride | Volinanserin-d4 (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity. | |||||||||||||||||||||
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Volinanserin | 99.62% | Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91. [Content Brief]
