138660-97-6
138660-97-6
Chemical Structure
Tuvirumab
Synonym(s): anti-hepatitis B; OST 577; SDZ-OST 577
- CAS No.: 138660-97-6
- Formula:N/A
- Molecular Weight:(144.04 kDa)
IUPAC Name: 2-((4-methylpentan-2-yl)amino)-5-((phenyl-d5)amino)cyclohexa-2,5-diene-1,4-dione
SMILES: [Tuvirumab]
Biological Activity: Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research[1][2].
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Tuvirumab | ≥99% | Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research. | ||||||||||||||||||||
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References
- [1]. N Ogata, et al. Markedly prolonged incubation period of hepatitis B in a chimpanzee passively immunized with a human monoclonal antibody to the a determinant of hepatitis B surface antigen. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3014-8. [Content Brief]
- [2]. R A Heijtink, et al. Administration of a human monoclonal antibody (TUVIRUMAB) to chronic hepatitis B patients pre-treated with lamivudine: monitoring of serum TUVIRUMAB in immune complexes. J Med Virol. 2001 Aug;64(4):427-34. [Content Brief]
