1426174-36-8
1426174-36-8
Chemical Structure
N-Nitrosonornicotine-d4
Synonym(s): (2S)-N'-Nitrosonornicotine-d4
- CAS No.: 1426174-36-8
- Formula:C9H7D4N3O
- Molecular Weight:181.23
IUPAC Name: (S)-3-(1-nitrosopyrrolidin-2-yl)pyridine-2,4,5,6-d4
InChIKey: XKABJYQDMJTNGQ-FUQHWSCXSA-N
SMILES: [2H]C1=C(C([2H])=NC([2H])=C1[C@@H]2CCCN2N=O)[2H]
Biological Activity: N-Nitrosonornicotine-d4 ((2S)-N'-Nitrosonornicotine-d4) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].
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N-Nitrosonornicotine-d4 | N-Nitrosonornicotine-d4 ((2S)-N'-Nitrosonornicotine-d4) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts. | |||||||||||||||||||||
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(±)-N′-Nitrosonornicotine-2,4,5,6-d4 | 99.12% | (±)-N′-Nitrosonornicotine-2,4,5,6-d4 is the deuterium labeled (±)-N′-Nitrosonornicotine-2,4,5,6. | ||||||||||||||||||||
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N-Nitrosonornicotine | 99.97% | N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774. [Content Brief]
