153438-49-4
Chemical Structure
Dapitant
Synonym(s): RPR 100893
- CAS No.: 153438-49-4
- Formula:C37H39NO4
- Molecular Weight:561.71
IUPAC Name: (S)-1-((3aS,4S,7aS)-4-hydroxy-4-(2-methoxyphenyl)-7,7-diphenyloctahydro-2H-isoindol-2-yl)-2-(2-methoxyphenyl)propan-1-one
InChIKey: CCIWVEMVBWEMCY-RCFOMQFPSA-N
SMILES: COC1=CC=CC=C1[C@]2(O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)[C@]5([H])[C@@]2([H])CN(C([C@@H](C)C6=C(OC)C=CC=C6)=O)C5
Biological Activity: Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation[1].
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Dapitant | Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation. | |||||||||||||||||||||
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