1626387-80-1
Chemical Structure
Zorifertinib
Synonym(s): AZD3759
- CAS No.: 1626387-80-1
- Formula:C22H23ClFN5O3
- Molecular Weight:459.90
IUPAC Name: 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (R)-2,4-dimethylpiperazine-1-carboxylate
InChIKey: MXDSJQHFFDGFDK-CYBMUJFWSA-N
SMILES: ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F
Biological Activity: Zorifertinib (AZD3759) is a potent, orally active, BBB-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively. Zorifertinib induces cancer cell apoptosis. Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zorifertinib | 99.37% | Zorifertinib (AZD3759) is a potent, orally active, BBB-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively. Zorifertinib induces cancer cell apoptosis. Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research. | ||||||||||||||||||||
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Keywords
