1640247-87-5
Chemical Structure
GS-9901
- CAS No.: 1640247-87-5
- Formula:C22H17ClFN9O
- Molecular Weight:477.88
IUPAC Name: (R)-2,4-diamino-6-(((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile
InChIKey: XDSXYMOZKDUASY-MRXNPFEDSA-N
SMILES: NC1=NC(N)=NC(N[C@H](C2CC2)C(N3C4=CN=CC=C4)=NC5=C(F)C=CC(Cl)=C5C3=O)=C1C#N
Biological Activity: GS-9901 is a highly selective and orally active PI3Kδ inhibitor with an IC50 of 1 nM. GS-9901 has ≥100 fold selectivity for PI3Kα (IC50 of 750 nM), PI3Kβ (IC50 of 100 nM) and PI3Kγ (IC50 of 190 nM). GS-9901 can be used for the study of rheumatoid arthritis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GS-9901 | 99.97% | GS-9901 is a highly selective and orally active PI3Kδ inhibitor with an IC50 of 1 nM. GS-9901 has ≥100 fold selectivity for PI3Kα (IC50 of 750 nM), PI3Kβ (IC50 of 100 nM) and PI3Kγ (IC50 of 190 nM). GS-9901 can be used for the study of rheumatoid arthritis. | ||||||||||||||||||||
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Keywords
