GS-9901

Cat. No.: HY-100694 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

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GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 1 nM. Has potential to treat rheumatoid arthritis.

For research use only. We do not sell to patients.

GS-9901 Chemical Structure

CAS No. : 1640247-87-5

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 1 nM. Has potential to treat rheumatoid arthritis^[1].

IC₅₀ & Target

IC50: 1 nM (PI3Kδ)^[1].

In Vivo

GS-9901 (0.3/1/3 mg/kg, orally, twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Lewis rats with established collagen-induced arthritis (CIA)^[1].
Dosage:	0.3 mg/kg, 1 mg/kg, and 3 mg/kg.
Administration:	Orally, twice-daily for 7 days starting on the 10th day after the second collagen immunization.
Result:	Demonstrated significant reduction in ankle swelling in rats treated with 0.3 mg/kg 35 (31% reduction), 1 mg/kg 35 (67%), and 3 mg/kg 35 (65%). Plasma concentrations measured on day 7 (12 h after last dose) were consistent with maintaining approximately 60%, 80%, and >90% inhibition of PI3Kδ at 0.3, 1.0, and 3 mg/kg doses, respectively, at trough levels.

Molecular Weight

477.88

Formula

C₂₂H₁₇ClFN₉O

CAS No.

1640247-87-5

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N)=NC(N[C@H](C2CC2)C(N3C4=CN=CC=C4)=NC5=C(F)C=CC(Cl)=C5C3=O)=C1C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (523.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0926 mL	10.4629 mL	20.9258 mL
5 mM	0.4185 mL	2.0926 mL	4.1852 mL
10 mM	0.2093 mL	1.0463 mL	2.0926 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (250 KB) SDS (0 KB)

COA (254 KB) HNMR (279 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0926 mL	10.4629 mL	20.9258 mL	52.3144 mL
	5 mM	0.4185 mL	2.0926 mL	4.1852 mL	10.4629 mL
	10 mM	0.2093 mL	1.0463 mL	2.0926 mL	5.2314 mL
	15 mM	0.1395 mL	0.6975 mL	1.3951 mL	3.4876 mL
	20 mM	0.1046 mL	0.5231 mL	1.0463 mL	2.6157 mL
	25 mM	0.0837 mL	0.4185 mL	0.8370 mL	2.0926 mL
	30 mM	0.0698 mL	0.3488 mL	0.6975 mL	1.7438 mL
	40 mM	0.0523 mL	0.2616 mL	0.5231 mL	1.3079 mL
	50 mM	0.0419 mL	0.2093 mL	0.4185 mL	1.0463 mL
	60 mM	0.0349 mL	0.1744 mL	0.3488 mL	0.8719 mL
	80 mM	0.0262 mL	0.1308 mL	0.2616 mL	0.6539 mL
	100 mM	0.0209 mL	0.1046 mL	0.2093 mL	0.5231 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-99011640247-87-5GS9901GS 9901Inhibitorinhibitorinhibit

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