2403782-38-5
2403782-38-5
Chemical Structure
TLR7/8/9 antagonist-3
- CAS No.: 2403782-38-5
- Formula:C28H33N7O
- Molecular Weight:483.61
InChIKey: UFXUWZOCUWYCIA-YKSBVNFPSA-N
SMILES: N#CC1=C2N=CC=CC2=C(N3C[C@@H](C)O[C@@H](CN4CCN(C5=CC6=C(C=N5)CCNC6)CC4)C3)C=C1
Biological Activity: TLR7/8/9 antagonist-3 is an orally active antagonist of TLR7, TLR8 and TLR9, with human IC50 values of 0.008 μM, 0.006 μM and 0.072 μM, respectively. TLR7/8/9 antagonist-3 blocks agonist-induced activation of hTLR7, hTLR8, hTLR9, mTLR7 and mTLR9, and reduces serum IFNα and TNFα levels. TLR7/8/9 antagonist-3 can be used in the research of autoimmune diseases[1].
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TLR7/8/9 antagonist-3 | TLR7/8/9 antagonist-3 is an orally active antagonist of TLR7, TLR8 and TLR9, with human IC50 values of 0.008 μM, 0.006 μM and 0.072 μM, respectively. TLR7/8/9 antagonist-3 blocks agonist-induced activation of hTLR7, hTLR8, hTLR9, mTLR7 and mTLR9, and reduces serum IFNα and TNFα levels. TLR7/8/9 antagonist-3 can be used in the research of autoimmune diseases. | |||||||||||||||||||||
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