2470908-90-6
2470908-90-6
Chemical Structure
YS-363
- CAS No.: 2470908-90-6
- Formula:C30H30N4O3
- Molecular Weight:494.58
InChIKey: QGMPQFYLGHXWOW-UHFFFAOYSA-N
SMILES: COC1=C(OCCCN2CCOCC2)C=C3C(N=CN=C3C4=C(C5=CC=CC=C5)NC6=C4C=CC=C6)=C1
Biological Activity: YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1].
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YS-363 | 99.52% | YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis. | ||||||||||||||||||||
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