252212-58-1
252212-58-1
Chemical Structure
GAPDH-IN-1
- CAS No.: 252212-58-1
- Formula:C20H18N2O5
- Molecular Weight:366.37
InChIKey: IQCCNCOQRRJSTE-UHFFFAOYSA-N
SMILES: C1(C2=CC(OCC3OC3)=CC=C2)=NN=C(C4=CC(OCC5OC5)=CC=C4)O1
Biological Activity: GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GAPDH-IN-1 | 98.1% | GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine. | ||||||||||||||||||||
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References
Keywords
