2549180-90-5
Chemical Structure
RAI-20
Synonym(s): H018
- CAS No.: 2549180-90-5
- Formula:C20H21FN4O3S2
- Molecular Weight:448.53
InChIKey: LZHJDLIJCBHEEZ-HUUCEWRRSA-N
SMILES: O=C([C@H]1[C@H](F)C1)NC2=CN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)S4)=CC=CC3=N2
Biological Activity:
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor (IC50=15.1 and 22.7 nM). RAI-20 exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a long half-life. In a collagen-induced arthritis rat model, RAI-20 shows significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and arthritis index. RAI-20 can be used for research on the pathogenesis of rheumatoid arthritis[1].
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RAI-20 | 98.66% | RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor (IC50=15.1 and 22.7 nM). RAI-20 exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a long half-life. In a collagen-induced arthritis rat model, RAI-20 shows significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and arthritis index. RAI-20 can be used for research on the pathogenesis of rheumatoid arthritis. |
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Keywords
