2620551-45-1
2620551-45-1
Chemical Structure
FLT3-IN-14
- CAS No.: 2620551-45-1
- Formula:C25H24N6O2S
- Molecular Weight:472.56
IUPAC Name: 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(4,5-dihydro-2H-imidazo[2',1':2,3]thiazolo[4,5-e]isoindol-8-yl)phenyl)urea
InChIKey: OAMPOKDQUZAAKE-UHFFFAOYSA-N
SMILES: CC(C)(C1=CC(NC(NC2=CC=C(C=C2)C3=CN4C5=C(SC4=N3)CCC6=CNC=C65)=O)=NO1)C
Biological Activity: FLT3-IN-14 is a potent FLT3 inhibitor with IC50s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model[1].
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FLT3-IN-14 | FLT3-IN-14 is a potent FLT3 inhibitor with IC50s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model. | |||||||||||||||||||||
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