2651196-69-7
2651196-69-7
Chemical Structure
CDK12-IN-4
- CAS No.: 2651196-69-7
- Formula:C20H20F2N8O
- Molecular Weight:426.42
IUPAC Name: 8-cyclopropyl-N-((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholinopyrazolo[1,5-a][1,3,5]triazin-4-amine
InChIKey: UXJVUCJEHIXDPU-UHFFFAOYSA-N
SMILES: FC1=C(F)C2=C(N=C(CNC3=NC(N4CCOCC4)=NC5=C(C6CC6)C=NN35)N2)C=C1
Biological Activity: CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].
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CDK12-IN-4 | CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1). | |||||||||||||||||||||
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