2692677-77-1
Chemical Structure
Cyanine7 DBCO
Synonym(s): Cy7 DBCO
- CAS No.: 2692677-77-1
- Formula:C58H65F6N4O2P
- Molecular Weight:995.13
IUPAC Name: (2R)-3-(((2-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamido)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate, diammonia salt
InChIKey: BCPAGJWDXBIMJR-UHFFFAOYSA-O
SMILES: O=C(CCCCC[N+]1=C(/C=C/C2=C/C(CCC2)=C/C=C3N(C)C4=C(C\3(C)C)C=CC=C4)C(C)(C)C5=C1C=CC=C5)NCCCCCC(N6C7=C(C#CC8=C(C6)C=CC=C8)C=CC=C7)=O.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Biological Activity: Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies[1][2].
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Cyanine7 DBCO | 97.65% | Cyanine7 DBCO (Cy7 DBCO) is a near-infrared fluorescent dye and an efficient bio-orthogonal quencher. Cyanine7 DBCO is formed by covalent connection of the near-infrared fluorescent dye Cy7 and the dibenzocyclooctyne (DBCO) functional group. After reacting with N3-Cy5-COOH, the fluorescence of Cy5 decreases by 90% within 90 minutes, and rapid signal attenuation can be observed within 2-5 minutes. Cyanine7 DBCO can be used for the study of deep tissue imaging and receptor-targeted therapeutic strategies. | ||||||||||||||||||||
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References
- [1]. R. Islam, et al. Design and Synthesis of Core–Shell Microgels with One-Step Clickable Crosslinked Cores and Ultralow Crosslinked Shells. Macromol Chem Phys. 2020, 221, 2000156.
- [2]. van der Wal S, et al. Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches. Chembiochem. 2018 Jun 4;19(16):1758–65. [Content Brief]
