2760536-87-4
2760536-87-4
Chemical Structure
Mesutoclax
Synonym(s): ICP-248
- CAS No.: 2760536-87-4
- Formula:C45H50ClN7O8S
- Molecular Weight:884.44
SMILES: CC(C)(CC1)CC(C2=CC=C(C=C2)Cl)=C1CN3[C@@H](CN(C4=CC(OC5=CN=C(NC=C6)C6=C5)=C(C=C4)C(NS(=O)(C7=CC([N+]([O-])=O)=C(C=C7)NC[C@H]8COCCO8)=O)=O)CC3)C
Biological Activity: Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM. Mesutoclax has weak activity against BCL-XL (IC50: ＞1000 nM). Mesutoclax can inhibit the activity of RS4;11 cells with an IC50 of 2.75 nM. Mesutoclax can be used in the study of cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mesutoclax | 98.69% | Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM. Mesutoclax has weak activity against BCL-XL (IC50: ＞1000 nM). Mesutoclax can inhibit the activity of RS4;11 cells with an IC50 of 2.75 nM. Mesutoclax can be used in the study of cancer. | ||||||||||||||||||||
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