2763421-81-2
Chemical Structure
PMM-302
Synonym(s): PMMB-302
- CAS No.: 2763421-81-2
- Formula:C38H45BrN2O6
- Molecular Weight:705.68
InChIKey: NHSHYKMYJNPZIF-DQAOMXIRSA-N
SMILES: C/C(C)=C\C[C@H](C(C(C1=C(O)C=CC(O)=C12)=O)=CC2=O)OC(CCC[C@@H]3[C@]4([H])[C@]5([H])[C@](CCCN5CCC4)([H])CN3CC6=C(C=CC=C6)Br)=O
Biological Activity: PMM-302 (PMMB-302) is a shikonin N-benzyl sophoridate derivative and a telomerase inhibitor. PMM-302 downregulates the telomerase core proteins DKC1 and NHP2 as well as TERT mRNA, and inhibits telomerase activity. PMM-302 induces G2/M phase cell cycle arrest and apoptosis, accompanied by downregulation of Bcl2, Bcl-XL, and FADD and upregulation of cleaved caspase-3 and cleaved caspase-9. PMM-302 can be used for lung cancer-related research[1].
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PMM-302 | PMM-302 (PMMB-302) is a shikonin N-benzyl sophoridate derivative and a telomerase inhibitor. PMM-302 downregulates the telomerase core proteins DKC1 and NHP2 as well as TERT mRNA, and inhibits telomerase activity. PMM-302 induces G2/M phase cell cycle arrest and apoptosis, accompanied by downregulation of Bcl2, Bcl-XL, and FADD and upregulation of cleaved caspase-3 and cleaved caspase-9. PMM-302 can be used for lung cancer-related research. | |||||||||||||||||||||
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