2837128-41-1
2837128-41-1
Chemical Structure
HDAC6-IN-13
- CAS No.: 2837128-41-1
- Formula:C23H22N4O
- Molecular Weight:370.45
IUPAC Name: 4-((11H-benzo[b]pyrido[4,3-f]azepin-11-yl)methyl)-N'-ethylbenzohydrazide
InChIKey: ZNRZSMMDQXGEGA-UHFFFAOYSA-N
SMILES: CCNNC(C1=CC=C(C=C1)CN2C3=CC=CC=C3C=CC4=C2C=NC=C4)=O
Biological Activity: HDAC6-IN-13 (Compound 35m) is a potent, highly selective, orally active HDAC6 inhibitor with an IC50 of 0.019 μM. HDAC6-IN-13 also inhibits HDAC1, HDAC2 and HDAC3 with IC50s of 1.53, 2.06 and 1.03 μM, respectively. HDAC6-IN-13 shows significant BBB permeability and anti-inflammatory activity[1].
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HDAC6-IN-13 | 98.08% | HDAC6-IN-13 (Compound 35m) is a potent, highly selective, orally active HDAC6 inhibitor with an IC50 of 0.019 μM. HDAC6-IN-13 also inhibits HDAC1, HDAC2 and HDAC3 with IC50s of 1.53, 2.06 and 1.03 μM, respectively. HDAC6-IN-13 shows significant BBB permeability and anti-inflammatory activity. | ||||||||||||||||||||
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References
Keywords
