2883813-32-7
Chemical Structure
LY1
- CAS No.: 2883813-32-7
- Formula:C20H19ClN4O3S
- Molecular Weight:430.91
IUPAC Name: 3-((2-(piperazin-1-yl)phenyl)amino)-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide hydrochloride
InChIKey: RVXKOLGQSWIVHC-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=NS(=O)(C3=C2C1=CC=C3)=O)NC4=C(C=CC=C4)N5CCNCC5.Cl
Biological Activity: LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1.5 μM and 2.3 μM for Mpro C145A protein and PLpro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 μM and 0.99 μM against Mpro and PLpro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY1 | 98.01% | LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1.5 μM and 2.3 μM for Mpro C145A protein and PLpro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 μM and 0.99 μM against Mpro and PLpro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme. | ||||||||||||||||||||
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Keywords
