3036531-21-9
3036531-21-9
Chemical Structure
J594
- CAS No.: 3036531-21-9
- Formula:C34H32Cl2N6O4S
- Molecular Weight:691.63
InChIKey: NKGNFOKODOFVPR-MVSYWXNCSA-N
SMILES: CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(N[C@H]5C[C@H](NC(/C=C/C(C6=C(Cl)C=C(OC)C=C6)=O)=O)C5)=O
Biological Activity: J594 is a BRD4 molecular glue degrader targeting RNF126, with DC50 values of 0.077 μM (long-form BRD4 in HEK293T cells) and 0.26 μM (short-form BRD4 in HEK293T cells), respectively. J594 induces proteasome- and RNF126-dependent degradation of BRD4[1].
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J594 | J594 is a BRD4 molecular glue degrader targeting RNF126, with DC50 values of 0.077 μM (long-form BRD4 in HEK293T cells) and 0.26 μM (short-form BRD4 in HEK293T cells), respectively. J594 induces proteasome- and RNF126-dependent degradation of BRD4. | |||||||||||||||||||||
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References
Keywords
