3048183-44-1
Chemical Structure
Blixeprodil hydrochloride
Synonym(s): GM-1020 hydrochloride
- CAS No.: 3048183-44-1
- Formula:C13H17ClFNO
- Molecular Weight:257.73
InChIKey: HQORNOFKXXCLLV-BTQNPOSSSA-N
SMILES: CN[C@]1(C2=CC=C(C=C2)F)C(CCCC1)=O.Cl
Biological Activity: Blixeprodil hydrochloride (GM-1020 hydrochloride) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a Ki of 3.25 µM in rat cortical tissues. Blixeprodil hydrochloride binds to the MK-801 ion channel site and blocks NMDA receptor-mediated currents in hyperpolarized states in a voltage-dependent manner. Blixeprodil hydrochloride modulates the power of cortical EEG frequency bands, alters spontaneous motor activity, and induces ataxia at high doses. Blixeprodil hydrochloride can be used in the research of depression[1].
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Blixeprodil hydrochloride | Blixeprodil hydrochloride (GM-1020 hydrochloride) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a Ki of 3.25 µM in rat cortical tissues. Blixeprodil hydrochloride binds to the MK-801 ion channel site and blocks NMDA receptor-mediated currents in hyperpolarized states in a voltage-dependent manner. Blixeprodil hydrochloride modulates the power of cortical EEG frequency bands, alters spontaneous motor activity, and induces ataxia at high doses. Blixeprodil hydrochloride can be used in the research of depression. | |||||||||||||||||||||
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Keywords
