3117527-92-8
Chemical Structure
IKKβ-IN-7
- CAS. Nr.: 3117527-92-8
- Formula:C45H42N2O11
- Molecular Weight:786.82
InChIKey: FSXKJYVXSBJCAG-OTFOICKMSA-N
SMILES: O=C(C([C@@H]1CC/C(COC(C2=CC=CC=C2C(OC3=CC4=C(C5=C(N=C4C=C3)C6=CC7=C(C(N6C5)=O)COC([C@]7(O)CC)=O)CC)=O)=O)=C\CC8)=C)O[C@@H]1[C@H]9O[C@@]98C
Biological Activity: IKKβ-IN-7 is an IKKβ inhibitor with an IC50 value of 9.44 μM. IKKβ-IN-7 induces DNA damage, S-phase cell cycle arrest, ROS accumulation, mitochondrial membrane potential loss, and apoptosis. IKKβ-IN-7 inhibits phosphorylation of p65 and IκBα, suppresses p65 nuclear translocation, and regulates NF-κB-controlled genes. IKKβ-IN-7 suppresses tumor growth in xenograft models and shows activity against colorectal cancer with low normal cell cytotoxicity. IKKβ-IN-7 can be used for the research of colorectal cancer[1].
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IKKβ-IN-7 | IKKβ-IN-7 is an IKKβ inhibitor with an IC50 value of 9.44 μM. IKKβ-IN-7 induces DNA damage, S-phase cell cycle arrest, ROS accumulation, mitochondrial membrane potential loss, and apoptosis. IKKβ-IN-7 inhibits phosphorylation of p65 and IκBα, suppresses p65 nuclear translocation, and regulates NF-κB-controlled genes. IKKβ-IN-7 suppresses tumor growth in xenograft models and shows activity against colorectal cancer with low normal cell cytotoxicity. IKKβ-IN-7 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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Keywords
