3125939-25-2
Chemical Structure
INCB161734
- CAS No.: 3125939-25-2
- Formula:C35H32Cl2F3N5O3
- Molecular Weight:698.56
InChIKey: SEUSFWYKCBJVKK-SDNRVHKZSA-N
SMILES: N#CCCC(C=C1C(N2[C@H]3[C@H]4CN[C@@H]3C4)=C5C=C2[C@H](N6C(OC)=O)[C@H]7C[C@@H]6C[C@@H]7OC(F)F)=C(C(F)=C1N=C5C)C8=C(C(Cl)=CC=C8)Cl
Biological Activity: INCB161734 is a potent, selective, and orally active small-molecule inhibitor of KRAS G12D. INCB161734 binds to the Switch II pocket and inhibits SOS1-dependent GDP/GTP exchange, ERK phosphorylation, and cell proliferation. INCB161734 exhibits antitumor activity in KRAS G12D-mutant tumor models. INCB161734 can be used in research related to KRAS G12D-mutant pancreatic cancer and colorectal cancer[1].
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INCB161734 | INCB161734 is a potent, selective, and orally active small-molecule inhibitor of KRAS G12D. INCB161734 binds to the Switch II pocket and inhibits SOS1-dependent GDP/GTP exchange, ERK phosphorylation, and cell proliferation. INCB161734 exhibits antitumor activity in KRAS G12D-mutant tumor models. INCB161734 can be used in research related to KRAS G12D-mutant pancreatic cancer and colorectal cancer. | |||||||||||||||||||||
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