3126204-69-8
3126204-69-8
Chemical Structure
PF-3166
- CAS No.: 3126204-69-8
- Formula:C43H42BrClN6O5S
- Molecular Weight:870.25
InChIKey: SZZJHKUNVBZYMT-RGULYWFUSA-N
SMILES: O=C([C@@H]1N(CC2=CC=C3C(N([C@H](C4=CC=CC=C4Br)CC(NC5=CC(NS(=O)(C)=O)=CC=C5C)=O)C(C6=CC=CC(OC7=CC=C(Cl)C=C7)=C6)=N3)=C2)CCC1)NC
Biological Activity: PF-3166 is a PAD2 inhibitor (IC50=150 nM) that is competitive with Ca2+. TPF-3166 insignificantly inhibits PAD3 or PAD4 (80 μM). PF-3166 also inhibits NH3 release (IC50=580 nM).[1].
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PF-3166 | PF-3166 is a PAD2 inhibitor (IC50=150 nM) that is competitive with Ca2+. TPF-3166 insignificantly inhibits PAD3 or PAD4 (80 μM). PF-3166 also inhibits NH3 release (IC50=580 nM).. | |||||||||||||||||||||
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