3129544-47-1
3129544-47-1
Chemical Structure
HLC40
- CAS No.: 3129544-47-1
- Formula:C38H33F6N3O6S
- Molecular Weight:773.74
InChIKey: RPLKZBXAMSCHBP-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(N(CC3=CC=C(C(F)(F)F)C=C3)C=C2CC4=CC=C(C(NS(=O)(C5=CC=CC=C5C(F)(F)F)=O)=O)C=C4OC)C=C1)OC6CCCC6
Biological Activity: HLC40 is a MLL1 histone methyltransferase inhibitor with an IC50 of 0.82 μM by binding to WDR5. HLC40 inhibits proliferation of cancer cells, induces apoptosis and upregulates cleaved caspase-3 levels. HLC40 exhibits antitumor efficacy in a murine AML xenograft model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HLC40 | 99.71% | HLC40 is a MLL1 histone methyltransferase inhibitor with an IC50 of 0.82 μM by binding to WDR5. HLC40 inhibits proliferation of cancer cells, induces apoptosis and upregulates cleaved caspase-3 levels. HLC40 exhibits antitumor efficacy in a murine AML xenograft model. | ||||||||||||||||||||
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