333415-38-6
333415-38-6
Chemical Structure
VU0071063
- CAS No.: 333415-38-6
- Formula:C18H22N4O2
- Molecular Weight:326.39
IUPAC Name: 7-(4-(tert-butyl)benzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: ZFZAIHKQJBMYLO-UHFFFAOYSA-N
SMILES: O=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
Biological Activity: VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC50=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0071063 | 99.71% | VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC50=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships. | ||||||||||||||||||||
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References
- [1]. Kharade SV, et al. Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063. J Pharmacol Exp Ther. 2019;370(3):350-359. [Content Brief]
- [2]. Raphemot R, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014;85(6):858-865. [Content Brief]
