509145-82-8
Chemical Structure
ATC0065 free base
- CAS No.: 509145-82-8
- Formula:C25H29BrF3N5O
- Molecular Weight:552.43
IUPAC Name: N2-((1s,4s)-4-((4-bromo-2-(trifluoromethoxy)phenethyl)amino)cyclohexyl)-N4,N4-dimethylquinazoline-2,4-diamine
InChIKey: FWKVXHBRMCTKHZ-KDURUIRLSA-N
SMILES: CN(C1=NC(N[C@H]2CC[C@H](CC2)NCCC3=C(C=C(C=C3)Br)OC(F)(F)F)=NC4=C1C=CC=C4)C
Biological Activity: ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities[1].
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ATC0065 free base | ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities. | |||||||||||||||||||||
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Keywords
