57817-83-1
Chemical Structure
N6,2′-O-Dimethyladenosine
- CAS No.: 57817-83-1
- Formula:C12H17N5O4
- Molecular Weight:295.29
IUPAC Name: (2R,3R,4R,5R)-2-(hydroxymethyl)-4-methoxy-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3-ol
InChIKey: GRYSXUXXBDSYRT-WOUKDFQISA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(N=CN=C3NC)=C3N=C2)O[C@@H]1CO
Biological Activity: N6,2′-O-Dimethyladenosine is a FTO substrate and reversible RNA modification. N6,2′-O-Dimethyladenosine acts as a demethylation substrate for FTO, which removes its methyl groups. N6,2′-O-Dimethyladenosine correlates with enhanced mRNA stability, improved translation efficiency and increased protein expression levels. N6,2′-O-Dimethyladenosine is applicable to research related to obesity and colorectal cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N6,2′-O-Dimethyladenosine | 99.86% | N6,2′-O-Dimethyladenosine is a FTO substrate and reversible RNA modification. N6,2′-O-Dimethyladenosine acts as a demethylation substrate for FTO, which removes its methyl groups. N6,2′-O-Dimethyladenosine correlates with enhanced mRNA stability, improved translation efficiency and increased protein expression levels. N6,2′-O-Dimethyladenosine is applicable to research related to obesity and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Ben-Haim MS, et al. Dynamic regulation of N6,2'-O-dimethyladenosine (m6Am) in obesity. Nat Commun. 2021 Dec 10;12(1):7185. [Content Brief]
- [2]. Jiang J, et al. m6AmPred: Identifying RNA N6, 2'-O-dimethyladenosine (m6Am) sites based on sequence-derived information. Methods. 2022;203:328-334. [Content Brief]
