78213-66-8
Chemical Structure
Penitrem E
- CAS No.: 78213-66-8
- Formula:C37H45NO6
- Molecular Weight:599.76
InChIKey: LTCFBVUSILPMGG-BRSLXYMHSA-N
SMILES: C=C1CC2=CC=C3C4=C2[C@@]5(O)[C@]1([H])C[C@]5([H])C(C)(C)O[C@@H]([C@@]6([H])[C@@]7(C)[C@](CC[C@@]8([H])[C@]9%10[C@H](O%10)[C@@H](O)[C@@H](C(C)=C)O8)(C)[C@@]9(O)CC6)C4=C7N3
Biological Activity: Penitrem E is an indole diterpenoid alkaloid with antitumor activity, isolated and extracted from Penicillium commune. Penitrem E is a BK channel antagonist. Penitrem E exerts its antagonistic effect by forming hydrogen bonds with the calcium-binding site of the BK channel, thereby upregulating the expression of TNF-α. Penitrem E can be used for research on breast cancer[1][2][3].
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Penitrem E | Penitrem E is an indole diterpenoid alkaloid with antitumor activity, isolated and extracted from Penicillium commune. Penitrem E is a BK channel antagonist. Penitrem E exerts its antagonistic effect by forming hydrogen bonds with the calcium-binding site of the BK channel, thereby upregulating the expression of TNF-α. Penitrem E can be used for research on breast cancer. | |||||||||||||||||||||
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References
- [1]. Sallam AA, et al. Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. MedChemComm. 2013 Oct;4(10). [Content Brief]
- [2]. Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5):157. [Content Brief]
- [3]. Sonjak S, et al. Comparison of secondary metabolite production by Penicillium crustosum strains, isolated from Arctic and other various ecological niches. FEMS microbiology ecology. 2005 Jun 01;53(1):51-60.
