94096-42-1
Chemical Structure
Dexnafenodone hydrochloride
Synonym(s): (S)-Nafenodone; LU-43706
- CAS No.: 94096-42-1
- Formula:C20H24ClNO
- Molecular Weight:329.86
InChIKey: IFLAOONIDYUCJU-BDQAORGHSA-N
SMILES: O=C1[C@](C2=CC=CC=C2)(CCN(C)C)CCC3=C1C=CC=C3.[H]Cl
Biological Activity: Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Dexnafenodone hydrochloride | Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pérez-Vizcaíno F, et al. Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. European journal of pharmacology. 1993 Feb 23;232(1):105-11. [Content Brief]
- [2]. Pérez-Vizcaino F, et al. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. European journal of pharmacology. 1991 Jun 18;199(1):43-50. [Content Brief]
