96316-00-6
96316-00-6
Chemical Structure
Metaphit
- CAS No.: 96316-00-6
- Formula:C18H24N2S
- Molecular Weight:300.46
IUPAC Name: 1-(1-(3-isothiocyanatophenyl)cyclohexyl)piperidine
InChIKey: FGSGBQAQSPSRJK-UHFFFAOYSA-N
SMILES: S=C=NC1=CC(C2(N3CCCCC3)CCCCC2)=CC=C1
Biological Activity: Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].
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Metaphit | Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms. | |||||||||||||||||||||
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References
- [1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74 [Content Brief]
- [2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22. [Content Brief]
Keywords
