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Pembrolizumab

(Synonyms: MK-3475; Lambrolizumab)
30 Cited Publications
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Based on 30 publication(s) in Google Scholar

Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

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  • Reinheit: 99.82%
  • CAS. Nr.: 1374853-91-4
  • Molecular Weight:145.24 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Experimental Validation Results for Pembrolizumab
  • Pembrolizumab Chemical Structure
    Pembrolizumab Chemical Structure
CAS. Nr.: 1374853-91-4
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow cytometry analysis of PD-1 overexpression HEK293 cells labelling PD-1 with Pembrolizumab at 67nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Loaded Pembrolizumab on AHC2 biosensor, can bind PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) with an affinity constant of 1.898E-09 M as determined in BLI assay.

  • 1/16

    Immobilized PD-1 Protein, Human can bind Pembrolizumab. The EC50 for this effect is 1.8 ng/mL.

  • 1/16

    Pembrolizumab purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Aug;45(8):1010-1037. [Abstract]

    Customer Validation
     Plots of tumor growth and tumor weight for each group (5 mice/group). The results showed that in mice, the combination of Pembrolizumab and Evolocumab significantly enhanced anti-tumor efficacy compared to Pembrolizumab alone (100 µg/mouse; i.p., every 7 days).

  • 1/16

    Pembrolizumab purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Jan 21;16(1):34. [Abstract]

    Customer Validation
     Pembrolizumab (pembro) (5-10 µg/mL, 24 h). AMM16 cells were transfected with control siRNA (siRNA ctrl; left panels) or AR siRNA (siRNA AR; right panels) and treated with the indicated ICIs at 35 μg/ml. The red fluorescence from the propidium iodide (PI) and the green fluorescence from the acridin orange (AO) staining indicate dead and total cells, respectively.

  • 1/16

    Pembrolizumab purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Aug 6;12(8):e009024. [Abstract]

    Customer Validation
     The PD-1 expression of macrophages isolated from the subcutaneous tumor microenvironment of mice was detected by flow cytometry (n=5). The results showed that Pembrolizumab (anti-PD-1 Ab) (20 µg/mL, 24 h) reduced PD-1 expression.

  • 1/16

    Pembrolizumab purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 May 9;12(5):465. [Abstract]

    Customer Validation
     4T1 tumor-bearing mice treated with anti-PD-1 mAbs (Pembrolizumab, 10 mg/kg; i.p.; twice a week) or LY2940002 (25 mg/kg; i.p.; twice a week) were euthanized at Day21 and the tumor volume were measured. The results showed that the administration of​ anti-PD-1 mAbs (Pembrolizumab), LY294002, or their combination​ significantly inhibited tumor growth in tumor-bearing mice.

  • 1/16

    Pembrolizumab purchased from MedChemExpress. Usage Cited in: ACS Appl Bio Mater. 2020 Oct 19;3(10):7080-7086. [Abstract]

    Customer Validation
     The immunofluorescence images of the tumor from the PBS- (A), random sequence- (B), anti-PD-1 antibody- (Pembrolizumab (5 mg/kg; s.c.; every other day for 16 days)) (C) and isotype antibody-treated group (D); The scale bar in the images is 50 µm.

  • Pembrolizumab Chemical Structure
    1/16
  • Pembrolizumab
  • Flow cytometry analysis of PD-1 overexpression HEK293 cells labelling PD-1 with Pembrolizumab at 67nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Loaded Pembrolizumab on AHC2 biosensor, can bind PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) with an affinity constant of 1.898E-09 M as determined in BLI assay.
  • Immobilized PD-1 Protein, Human can bind Pembrolizumab. The EC50 for this effect is 1.8 ng/mL.