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Antibacterial agent 219

Antibacterial agent 219 (Compound 2/75c) exhibits antibacterial activity by targeting cell wall biosynthesis. Antibacterial agent 219 inhibits methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC=0.5-32 µg/mL), Enterococcus faecium (MIC=2 µg/mL) and S. aureus (MIC=2 µg/mL).

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CAS No.: 1649473-91-5
Formule: C₂₂H₁₄FN₃O₂
Masse moléculaire:371.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antibacterial agent 219 Chemical Structure

CAS No.: 1649473-91-5

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- Cellular Effect
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	37 μg/mL Compound: 72c	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay	[PMID: 32184964]

Chemical Information

CAS No. 1649473-91-5
Masse moléculaire 371.36
Formule C₂₂H₁₄FN₃O₂
SMILES

FC1=CC=C(C=C1)OC2=CC=C(C3=NOC(C4=CC5=C(NC=C5)C=C4)=N3)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ceballos S, et al., Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00453-18. [Content Brief]

[2]. Chang M, et al., Non-beta lactam antibiotics. WO2016049586.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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