Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

  • Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00453-18. doi: 10.1128/AAC.00453-18.
Sara Ceballos  1 ,  Choon Kim  2 ,  Derong Ding  2 ,  Shahriar Mobashery  2 ,  Mayland Chang  3 ,  Carmen Torres  4
Affiliations
  • 1. Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain.
  • 2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
  • 3. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA [email protected] [email protected].
  • 4. Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain [email protected] [email protected].
PMID: 29866865 DOI: 10.1128/AAC.00453-18
Abstract

The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against Other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is ≤1 μg/ml.

Keywords
Enterococcus; MIC; MRSA; PBPs; Staphylococcus spp.; oxadiazole.
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