country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-186053

Copy Link Print Information

Antimalarial agent 56

Antimalarial agent 56 is an orally active antimalarial agent. Antimalarial agent 56 inhibits the growth of both drug-sensitive and drug-resistant Plasmodium falciparum strains in vitro. Antimalarial agent 56 can be used in malaria research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1220533-66-3
Formule: C₂₀H₂₁F₆N₃O
Masse moléculaire:433.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 56 Chemical Structure

CAS No.: 1220533-66-3

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Parasite :

In Vitro

Antimalarial agent 56 (WR319535) inhibits the growth of Plasmodium falciparum strains W2, D6, C235, and C2A with IC₉₀ values ranging from 75 to 275 ng/mL, and has a macrophage cytotoxicity LC₅₀ of 4110 ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antimalarial agent 56 (WR319535) (160 mg/kg; p.o.; daily; 3 consecutive days) produces a 7-day delay in mortality in Plasmodium berghei-infected ICR mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice^[1]
Dosage:

160 mg/kg
Administration:

p.o.; daily; 3 consecutive days
Result:

Produced a 7-day delay in mortality relative to vehicle control.

Chemical Information

CAS No. 1220533-66-3
Masse moléculaire 433.39
Formule C₂₀H₂₁F₆N₃O
SMILES

FC(F)(C1=NC2=C(C(C(CNCC34CNC(C4)CC3)O)=C1)C=CC=C2C(F)(F)F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Milner E, et al. Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Bioorg Med Chem Lett. 2010;20(4):1347-1351. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis