ARHGEF2 - Rho/Rac guanine nucleotide exchange factor 2 Gene

Also Known as GEF; Lfc; P40; GEFH1; LFP40; GEF-H1; NEDMHM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9181

About ARHGEF2

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,946,854-155,979,617 (from NCBI)

This gene has 21 transcripts (splice variants), 263 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung (RPKM 15.7), spleen (RPKM 12.3) and 24 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

ARHGEF2 Products (6)

mRNA	Protein	Name
NM_001162383.2	NP_001155855.1	rho guanine nucleotide exchange factor 2 isoform 1
NM_001162384.2	NP_001155856.1	rho guanine nucleotide exchange factor 2 isoform 2
NM_001350110.2	NP_001337039.1	rho guanine nucleotide exchange factor 2 isoform 4
NM_001350111.2	NP_001337040.1	rho guanine nucleotide exchange factor 2 isoform 4
NM_001350112.2	NP_001337041.1	rho guanine nucleotide exchange factor 2 isoform 5
NM_004723.4	NP_004714.2	rho guanine nucleotide exchange factor 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9857026	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	9857026	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14970201	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	9857026	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	9857026	GOA
involved in asymmetric neuroblast division	IDA IDA: Inferred from direct assay	28453519	GOA
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	11912491	GOA
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21887730	GOA
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	11912491	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19043560	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	28453519	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21887730	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	21887730	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21887730	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21887730	GOA
located in microtubule	IDA IDA: Inferred from direct assay	9857026	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21887730	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19043560	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21887730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF2 Protein Structure

RhoGEF

0
200
400
600
800
986 a.a.

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor 2	Rho/Rac guanine nucleotide exchange factor (GEF) 2

ARHGEF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ARHGEF2	Q92974	RPP25L	Homo sapiens	Q8N5L8	Validated Y2H	25416956
Intra	ARHGEF2	Q92974	RPP25L	Homo sapiens	Q8N5L8	Y2H Array	31515488
Intra	ARHGEF2	Q92974	FOXO3	Homo sapiens	O43524	Pull Down	25609649
Intra	ARHGEF2	Q92974	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	ARHGEF2	Q92974	YWHAZ	Homo sapiens	P63104	CoIP	14970201
Intra	ARHGEF2	Q92974	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

ARHGEF2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810959	GEF H1 Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P811176	Phospho-GEF H1 (Ser885) Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82132	GEF H1 Antibody (YA1877)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations	NEDMHM
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00954	ARHGEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARHGEF2	VGNC	VGNC:70013
Bos taurus	ARHGEF2	VGNC	VGNC:26111
Mus musculus	ARHGEF2	MGD	MGI:103264
Canis familiaris	ARHGEF2	VGNC	VGNC:38080
Felis catus	ARHGEF2	VGNC	VGNC:68143
Rattus norvegicus	ARHGEF2	RGD	RGD:1304659
Others	ARHGEF2	NCBI