Thermopsoside
Based on 1 Customer Validation
Thermopsoside is a CYP450 isoenzyme inhibitor and PXR activator. Thermopsoside inhibits CYP3A4, CYP2C19, CYP2D6 and CYP2C9 with IC50 values of 6.0 μM, 9.5 μM, 12.0 μM and 32.0 μM, respectively.
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- Pureté: 98.0%
- CAS No.: 19993-32-9
- Formule: C22H22O11
- Masse moléculaire:462.40
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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CYP2 |
CYP3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>20 μM
Compound: chrysoeriol-7-O-beta-D-glucopyranoside
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
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[PMID: 19778086] |
| Vero | CC50 |
200 μM
Compound: 5
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Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 23354072] |
Thermopsoside (0.3-30 μM; 48 h) activates PXR but exerts only marginal effects on the mRNA expression of CYP3A4, CYP1A2, CYP2C9, and P-gp in transiently transfected HepG2 cells[1].
Thermopsoside (100 μM; 10 min pre-incubation, 1 h with calcein-AM) does not inhibit P-glycoprotein activity in hMDR1-MDCK-II cells at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Transiently transfected HepG2 cells
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Concentration:0.3-30 μM
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Incubation Time:48 h
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Result:Exerted marginal effects on the mRNA expression of CYP3A4, CYP1A2, CYP2C9, and P-gp.
Chemical Information
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CAS No. 19993-32-9
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Appearance Solid
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Masse moléculaire 462.40
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Formule C22H22O11
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Color White to off-white
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SMILES
O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(OC)=C(O)C=C4)=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thermopsoside Related Classifications
HY-N6023 Related Classifications
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