1. PROTAC Cell Cycle/DNA Damage
  2. PROTACs CDK
  3. CPS2

CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

CPS2 Chemical Structure

CPS2 Chemical Structure

CAS No. : 2756741-90-7

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
5 mg USD 190 In-stock
10 mg USD 340 In-stock
25 mg USD 750 In-stock
50 mg USD 1320 In-stock
100 mg USD 2350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CPS2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for the research of acute myeloid leukemia[1].

IC50 & Target[1]

CDK2

24 nM (IC50)

In Vitro

CPS2 (5~333 nM; 12 hours; Ramos cells) stands out as the most potent degrader[1].
CPS2 (0.5~2 μM; HSCs) inhibits the proliferation of HSCs without inducing cytotoxicity. CPS2 (1~10000 nM; 48 hours; NB4 cells) induces potent CDK2 degradation. CPS2 (250 nM; 0~6 hours; Ramos and NB4 cells) rapidly induces the degradation of CDK2. CPS2 (10~500 nM; 6 hours; Ramos cells) induces only CDK2 degradation and does not directly perturb the other CDK proteins under subnanomolar concentration conditions. CPS2 (250 nM; 6 hours; NB4 cells) stands out as the most downregulated protein in cells treated for 6 hours with CPS2, confirming the selectivity of CPS2 for CDK2. CPS2 (0~250 nM; NB4 cells) makes the levels of CDK2 obviously decreased. CPS2 (2 μM; 3 days; HL60 cells) obviously promotes ATRA-induced CD11b upregulation[1].
The antileukemic effects of CPS2 are mediated by CDK2 degradation. CPS2 also induces granulocytic differentiation of HSCs, as assessed by cell morphological analysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Ramos cells
Concentration: 5~333 nM
Incubation Time: 12 hours
Result: Stood out as the most potent degrader.
Clinical Trial
Molecular Weight

890.94

Formula

C38H42N12O10S2

CAS No.
Appearance

Solid

Color

Yellow to green

SMILES

O=C(N1)CCC(N2C(C3=CC=CC(NCCOCCOCCN4N=NC(COCCNS(C5=CC=C(C=C5)NC6=NN(C(N)=N6)C(C7=C(C=CS7)C)=O)(=O)=O)=C4)=C3C2=O)=O)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 32.5 mg/mL (36.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1224 mL 5.6121 mL 11.2241 mL
5 mM 0.2245 mL 1.1224 mL 2.2448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.33%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1224 mL 5.6121 mL 11.2241 mL 28.0603 mL
5 mM 0.2245 mL 1.1224 mL 2.2448 mL 5.6121 mL
10 mM 0.1122 mL 0.5612 mL 1.1224 mL 2.8060 mL
15 mM 0.0748 mL 0.3741 mL 0.7483 mL 1.8707 mL
20 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.4030 mL
25 mM 0.0449 mL 0.2245 mL 0.4490 mL 1.1224 mL
30 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.9353 mL
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CPS2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CPS2
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HY-141680
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