CRBN ligand-619

Cat. No.: HY-W244832 Purity: ≥98.0%: Data Sheet
COA

SDS
Handling Instructions
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CRBN ligand-619 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-619 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-619 Chemical Structure

CAS No. : 2229724-66-5

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View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

CRBN ligand-619 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-619 can be linked to a target protein ligand via a linker to form a PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.13

Formula

C₁₂H₁₀BrN₃O₃

CAS No.

2229724-66-5

Appearance

Solid

SMILES

O=C1NC(=O)C(N2C(=O)C3=CC=C(Br)N=C3C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (241 KB) SDS (393 KB)

COA (248 KB) HNMR (285 KB)

Handling Instructions (2659 KB)

CRBN ligand-619 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-6192229724-66-5CRBN ligand619CRBN ligand 619Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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