2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. CSF1R-IN-3

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.

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CSF1R-IN-3

CSF1R-IN-3 Estructura química

No. CAS : 2760584-90-3

Tamaño Precio Stock Cantidad
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
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500 mg   Obtener un presupuesto  

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Based on 1 publication(s) in Google Scholar

CSF1R-IN-3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CSF1R-IN-3

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Descripciòn

CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1].

Peso molecular

574.67

Fòrmula

C30H38N8O4
No. CAS
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1NC2=CC(NC(NC3=NOC(C(C)(C)C)=C3)=O)=CC=C2/C1=C/C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 25 mg/mL (43.50 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7401 mL 8.7006 mL 17.4013 mL
5 mM 0.3480 mL 1.7401 mL 3.4803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 98.10%

SDS (251 KB)

COA (248 KB) HNMR (324 KB) LCMS (104 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7401 mL 8.7006 mL 17.4013 mL 43.5032 mL
5 mM 0.3480 mL 1.7401 mL 3.4803 mL 8.7006 mL
10 mM 0.1740 mL 0.8701 mL 1.7401 mL 4.3503 mL
15 mM 0.1160 mL 0.5800 mL 1.1601 mL 2.9002 mL
20 mM 0.0870 mL 0.4350 mL 0.8701 mL 2.1752 mL
25 mM 0.0696 mL 0.3480 mL 0.6961 mL 1.7401 mL
30 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4501 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0876 mL
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CSF1R-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-32760584-90-3c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Roralantiproliferativecolorectal cancer cellsmigrationmacrophagesM2-like macrophagesM1 phenotypeantitumor immunityInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
CSF1R-IN-3
Cat. No.:
HY-139990
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SAFETY DATA SHEET (SDS)

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