1. Protein Tyrosine Kinase/RTK
  2. c-Fms

CSF1R-IN-1 

Cat. No.: HY-101774
Handling Instructions

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.

For research use only. We do not sell to patients.

CSF1R-IN-1 Chemical Structure

CSF1R-IN-1 Chemical Structure

CAS No. : 2095849-04-8

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM.

IC50 & Target

IC50: 0.5 nM (CSF1R)[1]

In Vitro

CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay[1].

In Vivo

CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1].

Animal Model: Male CD-1 mice, 25-35 grams (8-11 weeks old)[1]
Dosage: 2 mg/kg IV or 10 mg/kg orally (Per Os)
Administration: i.v. or oral
Result: I.V.: Cmax=3.55, T1/2=0.87 P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64%
References
Molecular Weight

479.45

Formula

C₂₅H₂₀F₃N₅O₂

CAS No.

2095849-04-8

SMILES

CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1NC(C3=CC(C4=CN(C)N=C4)=CN=C3)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CSF1R-IN-1
Cat. No.:
HY-101774
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CSF1R-IN-1

Cat. No.: HY-101774