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Cat. No.: HY-N20725

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Cucurbitacin I 2-O-β-D-glucopyranoside

Cucurbitacin I 2-O-β-D-glucopyranoside is a cucurbitane-type triterpenoid glycoside. Cucurbitacin I 2-O-β-D-glucopyranoside can be isolated from the fruits of Citrullus colocynthis. Cucurbitacin I exhibits anti-tumor and anti-diabetic activities. Cucurbitacin I 2-O-β-D-glucopyranoside can be used in research related to cancer, inflammatory diseases and diabetes.

For research use only. We do not sell to patients.

CAS No.: 29803-94-9
Formula: C₃₆H₅₂O₁₂
Molecular Weight:676.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cucurbitacin I 2-O-β-D-glucopyranoside Chemical Structure

CAS No.: 29803-94-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	10 μM Compound: cucurbitacin I 2-O-beta-D-glucopyranoside	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 22044245]
A549	IC₅₀	10 μM Compound: cucurbitacin I 2-O-beta-D-glucopyranoside	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 22044245]
Bel-7402	IC₅₀	10 μM Compound: cucurbitacin I 2-O-beta-D-glucopyranoside	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 22044245]
HCT-8	IC₅₀	10 μM Compound: cucurbitacin I 2-O-beta-D-glucopyranoside	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 22044245]
HepG2	IC₅₀	390 μM Compound: 1	Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay	[PMID: 21459003]
HepG2	EC₅₀	195 μM Compound: 1	Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay	[PMID: 21459003]
HSC-T6	IC₅₀	256 μM Compound: 1	Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay	[PMID: 21459003]
HSC-T6	EC₅₀	4.15 μM Compound: 1	Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay	[PMID: 21459003]

In Vitro

Cucurbitacins E, I and Q have been shown to possess antitumor and antidiabetic activities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 29803-94-9
Molecular Weight 676.79
Formula C₃₆H₅₂O₁₂
SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)(C(C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=C4)=O)C)=CC3)(C(C[C@@]1([C@@]([C@@H](C2)O)([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)C)=O)C
Structure Classification
- Steroids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yoshikawa M, et al. Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis. Chemical & pharmaceutical bulletin. 2007 Mar;55(3):428-34. [Content Brief]

[2]. Ul Haq F, et al. Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry. Scientific reports. 2019 Nov 05;9(1):15992. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cucurbitacin I 2-O-β-D-glucopyranoside

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Cucurbitacin I 2-O-β-D-glucopyranoside

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

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Cucurbitacin I 2-O-β-D-glucopyranoside Related Classifications

HY-N20725 Related Classifications

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