Polymyxin B nonapeptide
Based on 3 publication(s) in Google Scholar
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
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- Reinheit: 99.83%
- CAS. Nr.: 86408-36-8
- Formel: C43H74N14O11
- Molecular Weight:963.13
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Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Polymyxin B nonapeptide
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Biologische Aktivität
Polymyxin B nonapeptide (2-32 μg/mL, 24 h) has a synergistic effect with Azithromycin (HY-17506)[1].
Polymyxin B nonapeptide (10 μg/mL) inhibits lipopolysaccharide (HY-D1056)-induced neutrophilic activation in a concentration-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli strains
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Concentration:2, 4, 8, 16, 32 μg/mL
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Incubation Time:24 h
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Result:Combinated with AZT caused a significant reduction the bacterial growth after 6 h and complete killing after 24 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 86408-36-8
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Appearance Solid
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Molecular Weight 963.13
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Formel C43H74N14O11
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Color White to off-white
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Sequence
Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)
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Sequence Shortening
T-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Adv Res
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria. [Abstract]2025 Jan 9:S2090-1232(24)00621-0. PMID: 39793961 -
Front Microbiol
Repurposing Antispasmodic Agent Otilonium Bromide for Treatment of Staphylococcus aureus Infections. [Abstract]2020 Jul 31:11:1720. PMID: 32849366 -
BMC Microbiol
Contezolid and polymyxin B nonapeptide combination reveals antibacterial synergy against multidrug-resistant Acinetobacter baumannii strains. [Abstract]2026 May 29. PMID: 42216156
Lösungsmittel & Löslichkeit
H2O : ≥ 100 mg/mL (103.83 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (285 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. [Content Brief]
[2]. Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. [Content Brief]
[3]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0383 mL | 5.1914 mL | 10.3828 mL | 25.9570 mL |
| 5 mM | 0.2077 mL | 1.0383 mL | 2.0766 mL | 5.1914 mL | |
| 10 mM | 0.1038 mL | 0.5191 mL | 1.0383 mL | 2.5957 mL | |
| 15 mM | 0.0692 mL | 0.3461 mL | 0.6922 mL | 1.7305 mL | |
| 20 mM | 0.0519 mL | 0.2596 mL | 0.5191 mL | 1.2979 mL | |
| 25 mM | 0.0415 mL | 0.2077 mL | 0.4153 mL | 1.0383 mL | |
| 30 mM | 0.0346 mL | 0.1730 mL | 0.3461 mL | 0.8652 mL | |
| 40 mM | 0.0260 mL | 0.1298 mL | 0.2596 mL | 0.6489 mL | |
| 50 mM | 0.0208 mL | 0.1038 mL | 0.2077 mL | 0.5191 mL | |
| 60 mM | 0.0173 mL | 0.0865 mL | 0.1730 mL | 0.4326 mL | |
| 80 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3245 mL | |
| 100 mM | 0.0104 mL | 0.0519 mL | 0.1038 mL | 0.2596 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Polymyxin B nonapeptide Related Classifications
HY-106783 Related Classifications
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