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  3. Magainin 1

Magainin 1 (Synonyms: Magainin I)

Cat. No.: HY-P0269
Handling Instructions

Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Magainin 1 Chemical Structure

Magainin 1 Chemical Structure

CAS No. : 108433-99-4

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Description

Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria[1][2][3].

In Vitro

Magainin 1 interacts with acidic lipids through electrostatic interactions followed by hydrophobic interactions to form an amphiphilic helix, inducing the leakage. Magainin 1 induces the leakage of calcein specifically out of negatively-charged vesicles. The peptide binds to bovine brain phosphatidylserine sonicated vesicles according to the Langmuir isotherm with a binding constant of 3.8×105 M-1 and a binding-site number of 0.10 per lipid molecule[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2409.85

Formula

C₁₁₂H₁₇₇N₂₉O₂₈S

CAS No.
Sequence

Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser

Sequence Shortening

GIGKFLHSAGKFGKAFVGEIMKS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Magainin 1
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