Laminin peptide CDPGYIGSR
Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury.
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- CAS. Nr.: 110590-60-8
- Formel: C40H62N12O14S
- Molecular Weight:967.06
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
Beschreibung
In Vitro
Laminin peptide CDPGYIGSR promotes the adhesion of human fibrosarcoma HT-1080 cells, with a maximum adhesion rate of 64% at a concentration of 60 μg; in contrast, its amide form (CDPGYIGSR-NH2) achieves a maximum adhesion rate of 100% at the same concentration; modification of the arginine residue in CDPGYIGSR with 1,2-cyclohexanedione completely abolishes its adhesive activity[2].
Laminin peptide CDPGYIGSR confirms the presence of this peptide segment (with or without PEG spacer arms) on EA75 films[3].
Laminin peptide CDPGYIGSR is chemically conjugated to PEG10 to form PEG10-CDPGYIGSR. When immobilized on EA75 films, this conjugate significantly enhances PC2 cell adhesion capacity but fails to induce obvious neurite outgrowth without extra laminin coating; after laminin modification, it markedly boosts PC12 cell adhesion, neurite generation and average neurite length[3].
Laminin peptide CDPGYIGSR (YIGSR) binds non-covalently to t-chitosan/HAp tubes and covalently to t-chitosan/HAp-SH tubes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 110590-60-8
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Molecular Weight 967.06
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Formel C40H62N12O14S
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Synonyms
Laminin (925-933)
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Sequence
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg
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Sequence Shortening
CDPGYIGSR
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Reinheit & Dokumentation
Verweise
[1]. Massia SP, et al. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. The Journal of biological chemistry. 1993 Apr 15;268(11):8053-9. [Content Brief]
[2]. Graf J, et al. A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochemistry. 1987 Nov 03;26(22):6896-900. [Content Brief]
[3]. Bhagwat N, et al. Biofunctionalization of PEDOT films with laminin-derived peptides. Acta biomaterialia. 2016 Sep 01;41:235-46. [Content Brief]
[4]. Castellano F, et al. An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1. Molecules (Basel, Switzerland). 2017 Dec 05;22(12):2151. [Content Brief]
[5]. Itoh S, et al. Effects of a laminin peptide (YIGSR) immobilized on crab-tendon chitosan tubes on nerve regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. 2005 May;73(2):375-82. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Laminin peptide CDPGYIGSR Related Classifications
HY-P0131 Related Classifications
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