Art. -Nr.: HY-B0848

Tricyclazole

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals.

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Reinheit: 98.64%
CAS. Nr.: 41814-78-2
Formel: C₉H₇N₃S
Molecular Weight:189.24

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Tricyclazole Chemical Structure

CAS. Nr.: 41814-78-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Pentaketide-derived melanin biosynthesis^[1]

In Vitro

Tricyclazole (16 μg/mL) causes morphological changes in Fonsecaea pedrosoi conidia and sclerotic cells^[1].
Tricyclazole (0.1-10 μg/mL; 24-48 h) inhibits melanization of Pyriculariaoryzae appressoria, prevents penetration of epidermal cell walls and Formvar membranes, and increases permeability of appressorial walls to solutes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tricyclazole (5-15 mg/kg; i.p.; 5 days/week for 2 weeks) causes dose-dependent hepatic damage in mice, including altered liver enzyme levels and histopathological changes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

adult NMRI mice (two months old, average weight 30 g)^[3]
Dosage:

5 mg/kg, 15 mg/kg
Administration:

intraperitoneal injection, 5 days a week for 2 weeks
Result:

Showed a significant decrease in hepatocyte number and increase in Kupffer cell number.
Increased serum levels of ALT and AST.
Decreased ALP.
Showed histopathological changes, including hepatocyte necrosis, degeneration, inflammatory cell infiltration, fibrosis, and sinusoid expansion.

Chemical Information

CAS. Nr. 41814-78-2
Appearance Solid
Molecular Weight 189.24
Formel C₉H₇N₃S
Color Light yellow to yellow
SMILES

CC1=C2N3C(SC2=CC=C1)=NN=C3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
J Agric Food Chem

2026 Jun 3;74(21):16299-16311. PMID: 42172023

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (660.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.2843 mL

26.4215 mL

52.8429 mL

5 mM

1.0569 mL

5.2843 mL

10.5686 mL

10 mM

0.5284 mL

2.6421 mL

5.2843 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Peterson L.G. Tricyclazole for Control of Pyricularia Oryzae on Rice: the Relationship of the Mode of Action and Disease Occurrence and Development. Pest Management in Rice. Springer, Dordrecht.

[2]. G.Lazarovits, et al. Tricyclazole induces melanin shunt products and inhibits altersolanol a accumulation by Alternaria solani. Pesticide Biochemistry and Physiology

[3]. Franzen AJ, et al. Effects of tricyclazole (5-methyl-1,2,4-triazol[3,4] benzothiazole), a specific DHN-melanin inhibitor, on the morphology of Fonsecaea pedrosoi conidia and sclerotic cells. Microsc Res Tech. 2006 Sep;69(9):729-37. [Content Brief]

[4]. Woloshuk C P, et al. Action of the antipenetrant, tricyclazole, on appressoria of Pyricularia oryzae[J]. Physiological Plant Pathology, 1983, 22(2): 245-IN21.

[5]. Fattahi E. Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole[J]. Medical Laboratory Journal, 2017, 11(6): 18-22.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.2843 mL	26.4215 mL	52.8429 mL	132.1074 mL
	5 mM	1.0569 mL	5.2843 mL	10.5686 mL	26.4215 mL
	10 mM	0.5284 mL	2.6421 mL	5.2843 mL	13.2107 mL
	15 mM	0.3523 mL	1.7614 mL	3.5229 mL	8.8072 mL
	20 mM	0.2642 mL	1.3211 mL	2.6421 mL	6.6054 mL
	25 mM	0.2114 mL	1.0569 mL	2.1137 mL	5.2843 mL
	30 mM	0.1761 mL	0.8807 mL	1.7614 mL	4.4036 mL
	40 mM	0.1321 mL	0.6605 mL	1.3211 mL	3.3027 mL
	50 mM	0.1057 mL	0.5284 mL	1.0569 mL	2.6421 mL
	60 mM	0.0881 mL	0.4404 mL	0.8807 mL	2.2018 mL
	80 mM	0.0661 mL	0.3303 mL	0.6605 mL	1.6513 mL
	100 mM	0.0528 mL	0.2642 mL	0.5284 mL	1.3211 mL

Keywords

Tricyclazole

3 Cited Publications

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Tricyclazole

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Publications Citing Use of MedChemExpress (MCE) Tricyclazole

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tricyclazole

Anti-Infection Compound Library

Antibacterial Compound Library

Rare Diseases Drug Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) Tricyclazole

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tricyclazole Related Classifications

HY-B0848 Related Classifications