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Cat. No.: HY-141648

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Antibacterial agent 219

Antibacterial agent 219 (Compound 2/75c) exhibits antibacterial activity by targeting cell wall biosynthesis. Antibacterial agent 219 inhibits methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC=0.5-32 µg/mL), Enterococcus faecium (MIC=2 µg/mL) and S. aureus (MIC=2 µg/mL).

For research use only. We do not sell to patients.

CAS No.: 1649473-91-5
Formula: C₂₂H₁₄FN₃O₂
Molecular Weight:371.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antibacterial agent 219 Chemical Structure

CAS No.: 1649473-91-5

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Biological Activity
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Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	37 μg/mL Compound: 72c	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay	[PMID: 32184964]

Chemical Information

CAS No. 1649473-91-5
Molecular Weight 371.36
Formula C₂₂H₁₄FN₃O₂
SMILES

FC1=CC=C(C=C1)OC2=CC=C(C3=NOC(C4=CC5=C(NC=C5)C=C4)=N3)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ceballos S, et al., Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00453-18. [Content Brief]

[2]. Chang M, et al., Non-beta lactam antibiotics. WO2016049586.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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References

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