MSR1 - macrophage scavenger receptor 1 Gene

Also Known as SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4481

About MSR1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:16,107,881-16,192,651 (from NCBI)

This gene has 14 transcripts (splice variants), 97 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in lung (RPKM 26.5), gall bladder (RPKM 9.7) and 19 other tissues.

Summary

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

MSR1 Products (4)

mRNA	Protein	Name
NM_001363744.1	NP_001350673.1	macrophage scavenger receptor types I and II isoform 4
NM_002445.4	NP_002436.1	macrophage scavenger receptor types I and II isoform type 2
NM_138715.3	NP_619729.1	macrophage scavenger receptor types I and II isoform type 1
NM_138716.3	NP_619730.1	macrophage scavenger receptor types I and II isoform type 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17237231	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSR1 Protein Structure

Macscav_rec

Collagen

SRCR

0
100
200
300
400
451 a.a.

Protein Preferred Names	Protein Names
macrophage scavenger receptor types I and II	macrophage acetylated LDL receptor I and II

MSR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MSR1	P21757	LEPROTL1	Homo sapiens	Q6FHL7	Validated Y2H	25416956
Intra	MSR1	P21757	LEPROTL1	Homo sapiens	Q6FHL7	Y2H Array	25416956
Intra	MSR1	P21757	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	MSR1	P21757	HOOK3	Homo sapiens	Q86VS8	Anti Tag CoIP	17237231
Intra	MSR1	P21757	NKG7	Homo sapiens	Q16617	Validated Y2H	25416956
Intra	MSR1	P21757	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	MSR1	P21757	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	MSR1	P21757	MALL	Homo sapiens	Q13021	Validated Y2H	25416956
Intra	MSR1	P21757	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	MSR1	P21757	MALL	Homo sapiens	Q13021	Y2H Array	25416956
Intra	MSR1	P21757	SEC22A	Homo sapiens	Q96IW7	Y2H Prey Pooling	25416956
Intra	MSR1	P21757	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	MSR1	P21757	SEC22A	Homo sapiens	Q96IW7	Y2H Array	25416956
Cross	MSR1	P21757	AABR07026291.1	Rattus norvegicus	Q7TQ77	Pull Down	17237231

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MSR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76781	CD204/MSR1 Protein, Human (HEK293, His)	P21757-1/NP_619729.1 (K77-L451)	≥ 95%, as determined by reducing SDS-PAGE.

MSR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80758	CD204 Antibody	WB	Human, Mouse, Rat
HY-P84182	CD204 Antibody (YA3879)	WB, FC, ELISA	Human
HY-P84182A	CD204 Antibody (YA3879)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovarian Disease Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Verruciform Xanthoma Of Skin	Verruciform Xanthoma Cutaneous Verruciform Xanthoma
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Silo Filler'S Disease	Silo Filler Disease Silo-Fillers' Disease
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18248	Msr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08724	MSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24728	Msr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992269	Anti-MSR1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MSR1	VGNC	VGNC:43448
Mus musculus	MSR1	MGD	MGI:98257
Macaca mulatta	MSR1	VGNC	VGNC:74939
Bos taurus	MSR1	VGNC	VGNC:31704
Felis catus	MSR1	VGNC	VGNC:68329
Rattus norvegicus	MSR1	RGD	RGD:1564316
Others	MSR1	NCBI