Disialyllacto-N-tetraose
Based on 1 Customer Validation
Disialyllacto-N-tetraose is a human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats.
For research use only. We do not sell to patients.
- Purity: 98.50%
- CAS No.: 61278-38-4
- Formula: C48H79N3O37
- Molecular Weight:1290.14
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Disialyllacto-N-tetraose (0-900 μM, 24 h) improves LPS (HY-D1056)-inhibited cell viability of Caco-2, promotes the expression of zonula occludens-1 (ZO-1), thereby maintaining the integrity of tight junctions, and protecting the neonatal intestinal barrier[2].
Disialyllacto-N-tetraose (300-900 μM, 20 h) regulates the activation and degranulation of mast cells, inhibits the release of histamine, chymase and tryptase from mast cells, thereby reducing the inflammatory response[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2
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Concentration:0-900 μM
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Incubation Time:24 h
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Result:Improved the cell viability inhibited by LPS.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats NEC models[2]
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Dosage:300 μM
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Administration:po in fomular milk for 3 days
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Result:Prevented the loosen/necrosis/loss of intestinal epithelial layer in the lesion site of intestinal tissue.
Chemical Information
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CAS No. 61278-38-4
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Appearance Solid
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Molecular Weight 1290.14
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Formula C48H79N3O37
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Color White to off-white
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SMILES
OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO[C@]4(O[C@@]([C@@H]([C@H](C4)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O)O[C@@H]5[C@H]([C@@H](O[C@@H]([C@@H]5O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)NC(C)=O)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jantscher-Krenn E, et al. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2012 Oct;61(10):1417-25. [Content Brief]
[3]. Zhang W, et al., Causative role of mast cell and mast cell-regulatory function of disialyllacto-N-tetraose in necrotizing enterocolitis. Int Immunopharmacol. 2021 Jul;96:107597. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Disialyllacto-N-tetraose Related Classifications
HY-N11503 Related Classifications
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